{"id":3441,"date":"2020-12-18T06:23:14","date_gmt":"2020-12-18T11:23:14","guid":{"rendered":"https:\/\/usmlerx.wpengine.com\/?post_type=podcast&#038;p=3441"},"modified":"2020-12-18T06:32:15","modified_gmt":"2020-12-18T11:32:15","slug":"neurodegenerative-diseases-foundations-and-framework","status":"publish","type":"podcast","link":"https:\/\/usmle-rx.com\/podcast\/neurodegenerative-diseases-foundations-and-framework\/","title":{"rendered":"Neurodegenerative Diseases: Foundations and Framework"},"content":{"rendered":"<p>Neurodegenerative diseases are a group of relatively common, progressive neurologic conditions that tend to affect people as they age. Basically, neurons in the brain die, causing functional losses. The part of the brain affected determines whether patients will experience dementia (deteriorated cognitive function), psychiatric disturbances, problems with movement, or a combination of these. These conditions usually are incurable.<\/p>\n<p>In this AudioBrick, we&#8217;ll cover the foundations and framework of neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Lewy body dementia, Huntington disease, amyotrophic lateral sclerosis, and Creutzfeldt-Jakob disease.<\/p>\n<p>After listening to this AudioBrick, you should be able to:<\/p>\n<ul class=\"section-container badge-list learning-objective-badge-list ng-tns-c547-41\">\n<li class=\"mat-badge mat-badge-warn ng-tns-c547-41 mat-badge-overlap mat-badge-above mat-badge-before mat-badge-medium ng-star-inserted\" data-rxvignette=\"true\" data-rxannotationidentifier=\"CP_NEU0039.3-LO00\"><span class=\"editable-content ng-tns-c547-41 medium-editor-element\" role=\"textbox\" data-rxannotationdata=\"learningObjective\" data-medium-editor-element=\"true\" aria-multiline=\"true\" data-medium-editor-editor-index=\"1\" data-placeholder=\"Type your text\">List the main neurodegenerative diseases.<\/span><span id=\"mat-badge-content-0\" class=\"mat-badge-content mat-badge-active\">1<\/span><\/li>\n<li class=\"mat-badge mat-badge-warn ng-tns-c547-41 mat-badge-overlap mat-badge-above mat-badge-before mat-badge-medium ng-star-inserted\" data-rxvignette=\"true\" data-rxannotationidentifier=\"CP_NEU0039.3-LO01\"><span class=\"editable-content ng-tns-c547-41 medium-editor-element\" role=\"textbox\" data-rxannotationdata=\"learningObjective\" data-medium-editor-element=\"true\" aria-multiline=\"true\" data-medium-editor-editor-index=\"1\" data-placeholder=\"Type your text\">Explain the mechanism of protein aggregation and neuronal loss that underlies all neurodegenerative diseases.<\/span><span id=\"mat-badge-content-1\" class=\"mat-badge-content mat-badge-active\">2<\/span><\/li>\n<li class=\"mat-badge mat-badge-warn ng-tns-c547-41 mat-badge-overlap mat-badge-above mat-badge-before mat-badge-medium ng-star-inserted\" data-rxvignette=\"true\" data-rxannotationidentifier=\"CP_NEU0039.3-LO02\"><span class=\"editable-content ng-tns-c547-41 medium-editor-element\" role=\"textbox\" data-rxannotationdata=\"learningObjective\" data-medium-editor-element=\"true\" aria-multiline=\"true\" data-medium-editor-editor-index=\"1\" data-placeholder=\"Type your text\">Describe common misfolded proteins pathogenic to degenerative central nervous system (CNS) disease, including hyperphosphorylated tau, amyloid, Lewy bodies, and prions.<\/span><span id=\"mat-badge-content-2\" class=\"mat-badge-content mat-badge-active\">3<\/span><\/li>\n<li class=\"mat-badge mat-badge-warn ng-tns-c547-41 mat-badge-overlap mat-badge-above mat-badge-before mat-badge-medium ng-star-inserted\" data-rxvignette=\"true\" data-rxannotationidentifier=\"CP_NEU0039.3-LO03\"><span class=\"editable-content ng-tns-c547-41 medium-editor-element\" role=\"textbox\" data-rxannotationdata=\"learningObjective\" data-medium-editor-element=\"true\" aria-multiline=\"true\" data-medium-editor-editor-index=\"1\" data-placeholder=\"Type your text\">Compare the clinical presentation, pathogenic abnormal proteins, and CNS locations of Alzheimer disease, Parkinson disease, Lewy body dementia, Huntington disease, amyotrophic lateral sclerosis, and Creutzfeldt-Jakob disease.<\/span><\/li>\n<\/ul>\n<p>You can also check out the original brick from our <a href=\"https:\/\/usmle-rx.scholarrx.com\/rx-bricks\/brick\/CP_NEU0039\">Neurology and Special Senses<\/a>, which is <a href=\"https:\/\/usmle-rx.scholarrx.com\/rx-bricks\/brick\/CP_NEU0039\">available for free<\/a>.<\/p>\n<p>Learn more about <a href=\"https:\/\/usmlerx.wpengine.com\/products\/rx-bricks\/\">Rx Bricks<\/a> by signing up for a free USMLE-Rx account: <a href=\"https:\/\/usmlerx.wpengine.com\/free-bricks\/\">www.usmle-rx.com<\/a><\/p>\n<p>You will get 5 days of full access to our <a href=\"https:\/\/usmlerx.wpengine.com\/products\/step-1-rx360\/\">Rx360+<\/a> program, including nearly 800 Rx Bricks.\u00a0 After the 5-day period, you will still be able to access over <strong>150 free bricks<\/strong>, including the entire collections for <strong>General Microbiology<\/strong> and <strong>Cellular and Molecular Biology<\/strong>.<\/p>\n<p>***<\/p>\n<p>If you enjoyed this episode, we&#8217;d love for you to leave a review on <a href=\"https:\/\/podcasts.apple.com\/us\/podcast\/the-rx-bricks-podcast\/id1530646481\">Apple Podcasts<\/a>.\u00a0 It helps with our visibility, and the more med students (or future med students) listen to the podcast, the more we can provide to the future physicians of the world.<\/p>\n<p>Follow <a href=\"https:\/\/usmlerx.wpengine.com\">USMLE-Rx<\/a> at:<br \/>\nFacebook: <a href=\"http:\/\/www.facebook.com\/usmlerx\">www.facebook.com\/usmlerx<\/a><br \/>\nBlog: <a href=\"http:\/\/www.firstaidteam.com\">www.firstaidteam.com<\/a><br \/>\nTwitter: <a href=\"https:\/\/twitter.com\/firstaidteam\">https:\/\/twitter.com\/firstaidteam<\/a><br \/>\nInstagram: <a href=\"https:\/\/www.instagram.com\/firstaidteam\/\">https:\/\/www.instagram.com\/firstaidteam\/<\/a><br \/>\nYouTube: <a href=\"http:\/\/www.youtube.com\/USMLERX\">www.youtube.com\/USMLERX<\/a><\/p>\n<p>Learn how you can access over 150 of our bricks for FREE: <a href=\"https:\/\/usmlerx.wpengine.com\/free-bricks\/\">https:\/\/usmlerx.wpengine.com\/free-bricks\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Neurodegenerative diseases are a group of relatively common, progressive neurologic conditions that tend to affect people as they age. Basically, neurons in the brain die, causing functional losses. The part of the brain affected determines whether patients will experience dementia (deteriorated cognitive function), psychiatric disturbances, problems with movement, or a combination of these. These conditions&hellip;","protected":false},"author":21,"featured_media":3442,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"sync_status":"synced","episode_type":"audio","audio_file":"https:\/\/episodes.castos.com\/5f410b62d04ef1-00454701\/Neurodegenerative-Diseases-FandF.mp3","podmotor_file_id":"329502","podmotor_episode_id":"301780","castos_file_data":"","cover_image":"","cover_image_id":"","duration":"00:29:49","filesize":"23.6 mb","filesize_raw":"24757459","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"full"},"tags":[52,82,84,85],"series":[133],"class_list":["post-3441","podcast","type-podcast","status-publish","has-post-thumbnail","hentry","tag-usmle","tag-neurology","tag-neurons","tag-neurotransmitters","series-the-rx-bricks-podcast"],"acf":[],"episode_featured_image":"https:\/\/usmle-rx.com\/wp-content\/uploads\/2020\/12\/180381.png","episode_player_image":"https:\/\/usmle-rx.com\/wp-content\/uploads\/2020\/09\/AudioBricks_CoverArt-1.png","download_link":"https:\/\/chtbl.com\/track\/EB2DCC\/usmle-rx.com\/podcast-download\/3441\/neurodegenerative-diseases-foundations-and-framework.mp3","player_link":"https:\/\/chtbl.com\/track\/EB2DCC\/usmle-rx.com\/podcast-player\/3441\/neurodegenerative-diseases-foundations-and-framework.mp3","audio_player":null,"episode_data":{"playerMode":"dark","subscribeUrls":{"apple_podcasts":{"key":"apple_podcasts","url":"https:\/\/podcasts.apple.com\/us\/podcast\/the-rx-bricks-podcast\/id1530646481","label":"Apple Podcasts","class":"apple_podcasts","icon":"apple-podcasts.png"},"google_play":{"key":"google_play","url":"https:\/\/www.google.com\/podcasts?feed=aHR0cHM6Ly93d3cudXNtbGUtcnguY29tL2ZlZWQvcG9kY2FzdA%3D%3D","label":"Google Play","class":"google_play","icon":"google-play.png"},"overcast":{"key":"overcast","url":"https:\/\/overcast.fm\/itunes1530646481\/the-rx-bricks-podcast","label":"Overcast","class":"overcast","icon":"overcast.png"},"spotify":{"key":"spotify","url":"https:\/\/open.spotify.com\/show\/6difsNR0giFPpNfJM2e5l2","label":"Spotify","class":"spotify","icon":"spotify.png"},"stitcher":{"key":"stitcher","url":"https:\/\/www.stitcher.com\/show\/the-rx-bricks-podcast","label":"Stitcher","class":"stitcher","icon":"stitcher.png"}},"rssFeedUrl":"https:\/\/usmle-rx.com\/feed\/podcast\/the-rx-bricks-podcast","embedCode":"<blockquote class=\"wp-embedded-content\" data-secret=\"deh2wgtvWB\"><a href=\"https:\/\/usmle-rx.com\/podcast\/neurodegenerative-diseases-foundations-and-framework\/\">Neurodegenerative Diseases: Foundations and Framework<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/usmle-rx.com\/podcast\/neurodegenerative-diseases-foundations-and-framework\/embed\/#?secret=deh2wgtvWB\" width=\"500\" height=\"350\" title=\"&#8220;Neurodegenerative Diseases: Foundations and Framework&#8221; &#8212; USMLE-Rx\" data-secret=\"deh2wgtvWB\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! 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