{"id":5461,"date":"2025-03-31T12:31:47","date_gmt":"2025-03-31T16:31:47","guid":{"rendered":"https:\/\/usmle-rx.com\/?p=5461"},"modified":"2025-03-31T12:39:01","modified_gmt":"2025-03-31T16:39:01","slug":"step-1-question-of-the-month-march","status":"publish","type":"post","link":"https:\/\/usmle-rx.com\/step-1-question-of-the-month-march\/","title":{"rendered":"STEP 1 Question of the Month (March)"},"content":{"rendered":"<h3>Conquer STEP 1, One Question at a Time! The answer is explained below.<\/h3>\n<p>&nbsp;<\/p>\n<p>A 4-year-old male is brought to a clinic because of a 1-week history of fever, cough, and runny nose and a 2-day history of intense coughing spells that last 1 to 2 minutes, occasionally followed by vomiting and dry heaving. His mother says he has not received any immunizations. Temperature is 38.5\u00b0C (101.3\u00b0F). WBC count is 22,000\/mm\u00b3 with 60% lymphocytes.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Which of the following pathogens is the most likely cause of this patient\u2019s symptoms?<\/strong><\/p>\n<p>A)\u00a0<em>Bordetella pertussis<\/em><\/p>\n<p>B)\u00a0<em>Corynebacterium diphtheriae<\/em><\/p>\n<p>C)\u00a0<em>Haemophilus influenzae<\/em><\/p>\n<p>D) Measles virus<\/p>\n<p>E)\u00a0<em>Streptococcus pneumoniae<\/em><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>Check the answer below \ud83d\udc47<\/p>\n<p>.<\/p>\n<p>.<\/p>\n<p>.<\/p>\n<p>.<\/p>\n<p>.<\/p>\n<p>.<\/p>\n<p>.<\/p>\n<p>.<\/p>\n<p>&nbsp;<\/p>\n<p>The correct answer is: <span style=\"color: #008000;\"><strong>A) <em>Bordetella pertussis<\/em>.<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"ng-tns-c4250228263-52\">High-Yield Summary<\/h3>\n<div class=\"rich-text high-yield-explanation ng-tns-c4250228263-52\" data-rxannotationdata=\"bottomLine\">\n<ul>\n<li>Pertussis, or whooping cough, presents as initial catarrhal coldlike symptoms, followed by a paroxysmal phase with violent, distinctive coughing (whoops) that can last several weeks.<\/li>\n<li>Whooping cough is caused by the gram-negative bacterium B pertussis.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"answer-wrapper ng-tns-c4250228263-52 --correct --selected ng-star-inserted --expanded\">\n<div id=\"cdk-accordion-child-1\" class=\"mat-expansion-panel-content ng-tns-c857250080-56 ng-trigger ng-trigger-bodyExpansion\" role=\"region\" aria-labelledby=\"mat-expansion-panel-header-1\">\n<div class=\"mat-expansion-panel-body ng-tns-c857250080-56\">\n<h3><strong>Step 1: Disease Diagnosis<\/strong><\/h3>\n<p>Initial coldlike symptoms followed by intensive coughing spells are consistent with\u00a0<b>whooping cough,<\/b>\u00a0or\u00a0pertussis. There is\u00a0leukocytosis\u00a0with lymphocytic dominance, as seen here. Initially resembling an upper respiratory infection (catarrhal phase), the infection progresses into the paroxysmal phase, which is characterized by distinctive forced intake of breath, or whoops. This child is currently in the paroxysmal phase.<\/p>\n<p><b>Disease Diagnosis:\u00a0<i>Bordetella pertussis<\/i><\/b><\/p>\n<p>Whooping\u00a0cough\u00a0is caused by the\u00a0gram-negative\u00a0bacterium<em><b>\u00a0Bordetella pertussis,<\/b>\u00a0and infection is vaccine-preventable. The\u00a0DTaP vaccine\u00a0contains acellular pertussis\u00a0antigens; the \u201c<\/em>aP\u201d component of the\u00a0vaccine\u00a0is several\u00a0<i>B pertussis<\/i>\u00a0toxins and filamentous\u00a0hemagglutinin.<\/p>\n<p>The other choices are incorrect:<\/p>\n<ul>\n<li><b>Measles\u00a0virus<\/b>\u00a0presents with a cough,\u00a0coryza,\u00a0conjunctivitis, high\u00a0fever, and Koplik spots on the buccal mucosa, followed by a characteristic\u00a0rash\u00a0with a downward spread.<\/li>\n<li><b><i>Streptococcus\u00a0pneumoniae<\/i><\/b>\u00a0presents with a productive cough with blood-tinged\u00a0sputum. Infection is generally localized to the lower lobes of the lungs.<\/li>\n<li><em><b>Corynebacterium diphtheriae<\/b><\/em><b>\u00a0<\/b>manifests as a\u00a0pharyngitis\u00a0that progresses to a pharyngeal pseudomembrane.<\/li>\n<li>Nontypable strains of\u00a0<em><b>Haemophilus influenzae<\/b><\/em>\u00a0may cause upper respiratory tract infections such as acute and chronic otitis and\u00a0sinusitis. Typeable strains, such as\u00a0<em>H influenzae<\/em>\u00a0type B, can cause\u00a0epiglottitis,\u00a0pneumonia, and\u00a0meningitis\u00a0in unimmunized individuals.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<hr \/>\n<h3><\/h3>\n<h3>Don\u2019t Wait \u2013 Sign Up Now!<\/h3>\n<div class=\"fl-module fl-module-rich-text fl-node-tups6r2nwj0v\" data-node=\"tups6r2nwj0v\">\n<div class=\"fl-module-content fl-node-content\">\n<div class=\"fl-rich-text\">\n<p>When you sign up for a free account, you\u2019ll have access to\u00a0<strong><a href=\"https:\/\/usmle-rx.com\/products\/step-1-rx360\/\" target=\"_blank\" rel=\"noopener\">Rx360+<\/a><\/strong> for the first five days after sign-up. Take advantage of that time to test-drive the most comprehensive study system on the market and see the difference we can make in your studying.<\/p>\n<p><a class=\"pp-button\" role=\"button\" href=\"https:\/\/account.scholarrx.com\/Account\/Login?ReturnUrl=%2Fconnect%2Fauthorize%2Fcallback%3Fclient_id%3DeCommerce%26response_type%3Dcode%26scope%3Dopenid%2520email%2520profile%26redirect_uri%3Dhttps%253A%252F%252Fwww2.usmle-rx.com%252Fopenid-connect%252Fgeneric%26state%3DAtlMPky5WbQy4h56eZjA37PdVhIUbiSZhPLEWjjxghU%26op%3Dfreetrial%26product%3D360TRIAL%26utm_source%3Dwebsite%26utm_medium%3DStep1ProductPage360%26utm_campaign%3DPlatform2.0LaunchFreeTrial\" target=\"_blank\" rel=\"noopener\" aria-label=\"Create My Free Account\"><span class=\"pp-button-text\">Create Your Free Account<\/span><\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"Conquer STEP 1, One Question at a Time! The answer is explained below. &nbsp; A 4-year-old male is brought to a clinic because of a 1-week history of fever, cough, and runny nose and a 2-day history of intense coughing spells that last 1 to 2 minutes, occasionally followed by vomiting and dry heaving. His&hellip;","protected":false},"author":43,"featured_media":5463,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"sync_status":"none","episode_type":"audio","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","castos_file_data":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","footnotes":""},"categories":[147,190],"tags":[],"series":[],"class_list":["post-5461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-step-1","category-exams"],"acf":[],"episode_featured_image":"https:\/\/usmle-rx.com\/wp-content\/uploads\/2025\/03\/USMLE-Rx-banner-2.png","episode_player_image":"https:\/\/usmle-rx.com\/wp-content\/uploads\/2020\/09\/AudioBricks_CoverArt-1.png","download_link":"","player_link":"","audio_player":false,"episode_data":{"playerMode":"dark","subscribeUrls":{"apple_podcasts":{"key":"apple_podcasts","url":"https:\/\/podcasts.apple.com\/us\/podcast\/the-rx-bricks-podcast\/id1530646481","label":"Apple Podcasts","class":"apple_podcasts","icon":"apple-podcasts.png"},"google_play":{"key":"google_play","url":"https:\/\/www.google.com\/podcasts?feed=aHR0cHM6Ly93d3cudXNtbGUtcnguY29tL2ZlZWQvcG9kY2FzdA%3D%3D","label":"Google Play","class":"google_play","icon":"google-play.png"},"overcast":{"key":"overcast","url":"https:\/\/overcast.fm\/itunes1530646481\/the-rx-bricks-podcast","label":"Overcast","class":"overcast","icon":"overcast.png"},"spotify":{"key":"spotify","url":"https:\/\/open.spotify.com\/show\/6difsNR0giFPpNfJM2e5l2","label":"Spotify","class":"spotify","icon":"spotify.png"},"stitcher":{"key":"stitcher","url":"https:\/\/www.stitcher.com\/show\/the-rx-bricks-podcast","label":"Stitcher","class":"stitcher","icon":"stitcher.png"}},"rssFeedUrl":"https:\/\/usmle-rx.com\/feed\/podcast\/the-rx-bricks-podcast","embedCode":"<blockquote class=\"wp-embedded-content\" data-secret=\"Ua9eMsakbW\"><a href=\"https:\/\/usmle-rx.com\/step-1-question-of-the-month-march\/\">STEP 1 Question of the Month (March)<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/usmle-rx.com\/step-1-question-of-the-month-march\/embed\/#?secret=Ua9eMsakbW\" width=\"500\" height=\"350\" title=\"&#8220;STEP 1 Question of the Month (March)&#8221; &#8212; USMLE-Rx\" data-secret=\"Ua9eMsakbW\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! 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